Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but These are unusual In this particular malignancy compared to other lymphoid neoplasms. CHD2 is mutated in 5% of CLL and 7% of MBL.75 The histone methyltransferase SETD2 and ARID1A are mutated in a little proportion of people. Of Observe, MYD88 mutations